Senin, 17 Februari 2014

A Potential Mechanism For Brain Cancer Growth

By Katie Arden


When it comes to the progression seen in brain cancer, there are many different details to look into. What are the ones which seem to be the most common, you may wonder? How exactly will certain drugs be reacted to when they are implemented for the sake of helping patients in this regard? From what has been, apparently a mechanism linked to this level of growth has been seen and it has the potential to be one that can help in the various research efforts to come.

Various companies on the matter, Voices against Brain Cancer included, can tell you about the vital nature of this condition and very few would be able to argue against such a point. Brain cancer is often viewed as the most serious medical condition and it is easy to see why, as there are many different intricacies to consider. Medical Xpress posted a report on the matter, saying that glioma was the most aggressive form of cancer seen there. There was also mention of assistance to be given by an FDA-approved food additive.

Medical Xpress spoke about how this food additive was surveyed by two individuals: professor of the University of Vermont Diane M. Jaworski, Ph.D., and Patrick Long, who is a former graduate of the institution. Their attention was placed on an enzyme by the name of aspartoacylase. What this does is break down another compound called N-acetyl-L-aspartate. For those who are unaware, NAA is the primary storage form of acetate seen in the brain. In general, it is able to turn genes on as well as off. In regards to glioma, NAA levels and ASPA expression are lowered.

There was work done in order to raise ASPA expression levels early on but the resulting proliferation did not prove to be positive. However, there was still hope, as the article spoke about the food additive referred to as glyceryl triacetate, which would be used in order to assist glioma patients. GTA has been utilized in the past in order to help patients with Canavan disease, which is an inherited condition that can bring damage to the brain cells. Children who are born with Canavan disease die during infancy.

According to the article, GTA was put to use and the results that came to surface were rather positive. It showed lower levels of growth in terms of glioma stem cells but another positive to consider was that the healthy cells remained unharmed. This, to me, is the most important factor to consider about this condition. It shows that there is a level of potential to consider, especially when considering that toxicity and side-effects alike are practically nonexistent with GTA being put to use for research purposes.




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